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药物PNEC推导应考虑不同毒理学终点·Derivation of aquatic predicted no-effect concentration (PNEC) for ibuprofen and sulfamethoxazole based on various toxicity endpoints and the associated risks

药物通过与生物体内的受体结合产生药理作用,研究证明其可能作用于非目标生物体。鉴于不同药物的药理学作用差异,其对生物体的毒作用模式也可能有所不同,因此,传统的毒理学终点可能难以反映药物的毒作用模式。药物是否存在特殊的毒作用模式是值得关注的研究课题。本研究检验两个假设:(1)不同的药物其敏感性终点有所差异;(2)传统的毒理学终点不能反映所有药物对非目标生物的毒性。结果表明,药物的确可能存在各异的毒理效应,且依据与传统的毒理学终点所制定的水环境基准可能无法为水生生物提供足够的保护。该成果发表在Chemosphere上。【全文链接

Abstract

For pharmaceuticals, the ecological risk assessment based on traditional endpoints of toxicity could not be properly protective in the long run since the mode of action could vary because they are intended for different therapeutic uses. In this study, the predicted no-effect concentrations (PNECs) of two selected pharmaceuticals, ibuprofen (IBU) and (SMX), were derived based on either traditional endpoints of survival and growth data or some nonlethal endpoints such as reproduction, biochemical and molecular data. The PNECs of IBU based on biochemical-cellular and reproduction data were 0.018 and 0.026 ug·L-1 that were significantly lower than those derived from other endpoints, while the lowest PNEC for SMX derived from growth data with the concentration of 0.89 ug·L-1. Ecological risk assessment was performed for IBU and SMX to the aquatic environment by applying hazard quotient and probabilistic distribution based quotient (DBQs) methods. The results showed that the probability of DBQs of IBU exceeding 0.1 was 11.2%, while for SMX the probability was 0.9% that could be neglected.

Please cite it as

Qiusen Huang, Qingwei Bu, Wenjue Zhong, Kaichong Shi, Zhiguo Cao, Gang Yu. Derivation of aquatic predicted no-effect concentration (PNEC) for ibuprofen and sulfamethoxazole based on various toxicity endpoints and the associated risks. Chemosphere, 2018, 193, 223-229.

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